The 49ers are likely to be without George Kittle, Christian McCaffrey and Deebo Samuel for Sunday's game at the Rams.

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

The 49ers are partly to blame for why Christian McCaffrey will be out at least four games and possibly more as he nurses ...

San Francisco 49ers star Christian McCaffrey could miss more than the minimum of four games required on injured reserve, ...

ESPN sources: 49ers officially are placing All-Pro RB Christian McCaffrey on injured reserve due to his calf tightness and ...

San Francisco 49ers running back Christian McCaffrey is going to be out for at least the next four games. Per ESPN's Adam ...

The San Francisco 49ers are without running back Christian McCaffrey for at least four weeks. A report from NFL Media’s Ian ...

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...

Christian McCaffrey will miss at least the 49ers’ first five games this season as they put him on the injured reserve list ...

The reigning NFC champions faced a puzzling loss on Sunday. The San Francisco 49ers lost to the Minnesota Vikings 23-17 as ...

San Francisco 49ers' George Kittle is listed as doubtful for Sunday's game against the Rams. He joins Christian McCaffrey and ...