One major reason why it has been difficult to develop an effective HIV vaccine is that the virus mutates very rapidly, ...

HIV has a cunning strategy—it infects specific immune cells, hijacks their genetic program ... The capsid, despite its size, cleverly mimics the structure of these transporters.

to show how structure–function relationships of Env proteins can inform the design of an effective HIV-1 vaccine. With special emphasis on the variable regions of gp120, we highlight the ...

Direct viral neutralization can be demonstrated by protection of peripheral blood mononuclear cells from infection by a given HIV strain as measured by reduction of p24 antigen in culture ...

Figure 1: Domain organization and structure of ALIX. The papers discussed here greatly enhance our understanding of how HIV-1 and related viruses make contact with the cellular machinery that they ...

Researchers have shown that they can generate a strong immune response against HIV with two doses of a vaccine given one week apart.

The HIV capsid is a cone-shaped structure that provides a container for viral proteins and enzymes. When the virus enters a target cell, the capsid opens up in a pre-programmed sequence to allow HIV ...

Scientists say they have successfully eliminated HIV from infected cells, using Nobel Prize-winning Crispr gene-editing technology. Working like scissors, but at the molecular level, it cuts DNA ...

Scientists have identified the protein complex that gives the hepatitis C virus the ability to bind and infect cells.

Efavirenz is an important drug for treating HIV infection, but it causes negative neuropsychiatric effects in roughly 50% of ...

Determinants of HIV cell tropism & chemokine receptor usage The V3 loop of HIV-1 gp120 is a primary determinant of cell tropism and chemokine receptor usage, whereas the V1/V2 region is involved ...

Prior vaccine immunogens have not generated bNAbs with the physical structure ... in people without HIV, and that their ...