The gene PSEN2 encodes presenilin-2, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. Missense mutations in PSEN2 are a rare cause of early onset Alzheimer's disease.
reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but ...
The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...
The 17q21.31 microduplication is a copy number variant encompassing the CRHR1, MAPT, STH, and KANSL1 genes. Clinical phenotypes similar to Alzheimer's disease (AD) have been reported in several ...
Oregon Health and Science University 3181 SW Sam Jackson Park Road Mail Code CR 131 Portland, OR97239 United States Visit Website Contact: Jeffrey Kaye, M.D. Phone: 503-494-6976 Fax: 503-494-7499 ...
901 E. Willeta Street Phoenix, AZ85006 United States Visit Website Contact: Eric Reiman, M.D. Phone: 602-839-6999 Fax: 602-239-6253 E-mail: eric.reiman@bannerhealth ...
Scientists led by Wiep Scheper of Amsterdam University Medical Center are flipping the script on granulovacuolar degeneration bodies. Historically, GVBs have been considered a sign of impending ...
Studies have confirmed the existence of neurogenesis in the adult human brain, but whether newborn neurons bolster cognitive abilities remains controversial. In the February 25 Nature, scientists led ...
The notion that lithium might treat Alzheimer’s was revived last year when scientists reported that the brains of people and mice with amyloid pathology are deficient in the metal ion, and that the ...
The notion that lithium might treat Alzheimer’s was revived last year when scientists reported that the brains of people and mice with amyloid pathology are deficient in the metal ion, and that the ...
Cerebral small vessel disease is an umbrella term for disorders that cause the brain’s small blood vessels to stiffen, narrow, clog, or leak. cSVD increases a person’s risk for stroke and is a common ...