High prevalence of autoantibodies against glutamic acid decarboxylase (GAD-Ab) in stiff man syndrome (SMS) not only helps diagnosis, but also suggests immune mediated impairment of GABAergic functions ...

Correspondence to: Professor J Wardlaw, Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; jmw{at}skull.dcn.ed.ac.uk Objectives: To determine the ...

Correspondence to Dr Dearbhla Kelly, Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU, UK; ...

University of Iowa, The Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA Objective: The objective of the Predict-HD study is to use genetic, neurobiological and refined clinical ...

As a chronic progressive disease, Parkinson's disease (PD) has a presymptomatic interval; that is, a period during which the pathological process has begun, but motor signs required for the clinical ...

1 MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK 2 Department of Psychology, Institute of Psychiatry, King's College London, London, UK 3 ...

Objectives To evaluate the validity, reliability, responsiveness and meaningful change threshold of the Inclusion Body Myositis (IBM) Functional Rating Scale (FRS). Methods Data from a large 20-month ...

OBJECTIVE To test the hypothesis that delusions are associated with asymmetric involvement of the temporal lobe regions in Alzheimer's disease. METHODS Temporal lobe atrophy was assessed with a linear ...

Movement disorders arise from the complex interplay of multiple changes to neural circuits. Successful treatments for these disorders could interact with these complex changes in myriad ways, and as a ...

Background: Mild cognitive impairment (MCI) has been considered a transitional state between normal aging and dementia, characterised by memory impairment but normal general cognitive functioning.

The brain is in a constant state of dynamic change, for example switching between cognitive and behavioural tasks, and between wakefulness and sleep. The brains of people with epilepsy have additional ...