England have suffered significant injury news ahead of the Six Nations with Jamie George set to miss their opening fixture against Ireland. Hooker George, who has been replaced by Maro Itoje as captain,

England vice-captain Jamie George has been ruled out of the Six Nations opener against defending champions Ireland on February 1, the Rugby Football Union announced on Tuesday.

Jamie George is one of five players who have been forced to withdraw from England's Six Nations squad - a week after he was deposed as captain.

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.

Hooker Jamie George will miss England’s visit to Ireland to open the Six Nations next week after he injured a hamstring last weekend.

England have been struck by an injury crisis less than a fortnight before the Guinness Six Nations with vice-captain Jamie George heading a significant list of withdrawals from Steve Borthwick’s squad.

England have been bit by the loss of Jamie George for their Guinness Six Nations opener against Ireland ... after being taken to the squad’s pre-Championship training camp in Girona to continue ...

England expect Jamie ... the Six Nations launch event here in the Italian capital, saying ‘you always anticipate changes’ and ‘you’ve got to adapt’. Asked about the extent of George ...

Brousset refereed in last year’s Rugby Championship and the Autumn ... forced into a major reshuffle on the eve of the Six Nations with Jamie George, Alex Coles, Jack van Poortvliet and Alex ...

England lose Jamie George for Six Nations opener as injuries mount before Ireland clash - Alex Mitchell is also doubtful for Dublin trip, with Alex Coles, Jack van Poortvliet and Alex Dombrandt all ru

Former England captain Jamie George is now a major injury doubt for the Six Nations after picking up a knock in Saracens’ shock 32-24 defeat to Castres last night. George was named England skipper ahead of last year’s Championship,

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