In the early days of President Donald Trump’s second term, Alaska Sen. Lisa Murkowski had openly challenged or rebuked him at least three times.

Lisa Murkowski, the senior United States senator from Alaska, has held the seat since 2002. When will she be up for re-election? Here's what we know.

Sen. Lisa Murkowski (R-Alaska) joined with a Danish lawmaker on Monday to push back against President Trump’s continued insistence that U.S. control of Greenland is necessary for American national

Sen. Lisa Murkowski is opposing the nomination of Pete Hegseth to be President Donald Trump's Defense secretary.

Alaska U.S. Sen. Lisa Murkowski on Thursday announced on social media that she would vote against confirming Pete Hegseth to lead the U.S. Department of Defense. Republicans have a 53-seat majority in the U.

The Alaska Republican plans to vote against the confirmation of Pete Hegseth to lead the Department of Defense.

Moderate GOP Sen. Lisa Murkowski of Alaska has broken her silence, saying she won't be voting to confirm Pete Hegseth as secretary of defense.

Sen. Lisa Murkowski of Alaska became the first Republican to come out against Pete Hegseth ’s nomination to become the Secretary of Defense.

President Donald Trump signed an executive order to rename Denali, North America’s tallest peak, back to its former name, Mount McKinley.

Sen. Lisa Murkowski (R-AK) announced Thursday that she would vote against confirming Pete Hegseth, President Donald Trump's nominee for Secretary of Defense.

President Trump on Friday said he wasn’t expecting Republican Sens. Lisa Murkowski (Alaska) and Susan Collins (Maine) to vote against his controversial nominee for secretary of Defense: Army

Sen. Lisa Murkowski won't support Hegseth to lead Pentagon, becoming the first Republican to oppose a Trump Cabinet pick.