The nuclear envelope (NE) is a dynamic and selective barrier that organizes genome function and nucleocytoplasmic ...

Mitochondrial defects are associated with the development of diseases such as type 2 diabetes (T2D). Studies in mice and in human tissues, by researchers at the University of Michigan, have now found ...

The structural and functional characteristics of mitochondria shape their role as signaling organelles, with far-reaching effects regarding immune responses, inflammatory processes, and diseases. A ...

TAMPA, Fla.--(BUSINESS WIRE)--Verséa Discovery, Inc., a Florida-based company dedicated to advancing scientific research and development in the area of personalized and precision medicine, has ...

MITOLINE ™ Algorithm Powers Development of First-in-Class Small Molecules Targeting a Mitochondrial Carrier for Inflammatory Metabolic Diseases – A Market Projected to Exceed $120 billion by 2030 Neve ...

Small-molecule mitochondrial transcription factor A modulators stabilize mtDNA, preventing cytosolic escape and suppressing cGAS-STING interferon signaling, while improving bioenergetics and fibrosis ...

When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory response. It’s just as important to be able to resolve that inflammation and ...

Mitochondrial dysfunction manifests as structural damage (swelling, cristae rupture, increased volume/decreased numerical density), energy metabolism abnormalities (reduced COX and Complex I-III ...

Stanford University-led researchers report that tumor cells hijack mitochondria from immune cells, reducing anti-tumor immune function and activating cGAS-STING and type I interferon signaling that ...