Validated, tissue-specific library enables customisable and controllable liver-targeted gene expression with high specificity and minimal off-target activity in muscle tissue ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

For decades, biologists have known that the instructions for life are written in DNA, yet the vast majority of those letters seemed to sit in the dark, doing little that was obvious. Now a new ...

Once disregarded as “junk DNA,” scientists now know that this molecular dark matter is crucial for determining gene activity ...

Delivery of therapeutic genes is essential for gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Researchers reckon it could dramatically accelerate understanding of how DNA influences disease, cancer, and drug discovery.

What do your genes have to do with growing old? Quite a lot. But is it due to the actual DNA, or the way those genes are expressed? KPBS sci-tech reporter Thomas Fudge has more on new research that ...

Psoriasis is a common inflammatory skin disease linked to several long-term health conditions, such as heart disease, ...

By Tarun Sai Lomte Blood-based DNA repair and stress-response signals reveal a brief molecular window preceding Parkinson’s ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...

DeepMind’s AlphaGenome AI model could help solve the problem of predicting how variations in noncoding DNA shape gene ...